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Topics in Evidence-Based Pharmacy Practice
1/14/2011: Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma
Michelle Tyra
Feik School of Pharmacy, University of the Incarnate Word, San Antonio, Texas
Tina Lopez
Feik School of Pharmacy, University of the Incarnate Word, San Antonio, Texas
Excerpt:"Asthma is a common chronic disorder in both children and adults. Asthma involves airflow obstruction, bronchial hyperresponsiveness, and underlying inflammation. For patients not currently controlled on a low dose inhaled glucocorticoid, the next step up is to either double the glucocorticoid dose or add a long-acting beta-agonist (LABA).1 Doubling the dose of a inhaled glucocorticoid has not been shown in studies to improve asthma.2 Moreover, LABAs are an effective treatment option, but there is an increased concern about the safety of LABAs.3 Currently, tiotropium is only approved for the use in COPD.4 Tiotropium might be a potential alternative to the current step-up therapy treatment options. ..."
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