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Harrison's Online
Featuring the complete contents of Harrison's Principles of
Internal Medicine, 17e

Anthony S. Fauci, Eugene Braunwald, Dennis L. Kasper, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, and Joseph Loscalzo, Eds.

Preface   Copyright   Contributors



CONTENTS

Part 1. Introduction to Clinical Medicine
 Chapter 1.The Practice of Medicine
 Chapter 2.Global Issues in Medicine
 Chapter 3.Decision-Making in Clinical Medicine
 Chapter 4.Screening and Prevention of Disease
 Chapter 5.Principles of Clinical Pharmacology
 Chapter 6.Women's Health
 Chapter 7.Medical Disorders during Pregnancy
 Chapter 8.Medical Evaluation of the Surgical Patient
 Chapter 9.Geriatric Medicine
 Chapter 10.Complementary and Alternative Medicine
 Chapter 11.Palliative and End-of-Life Care
Chapter e1.The Safety and Quality of Health Care
Chapter e2.Economic Considerations in the Practice of Medicine
Chapter e3.Racial and Ethnic Disparities in Health Care
Chapter e4.Ethical Issues in Clinical Medicine

Part 2. Cardinal Manifestations and Presentation of Diseases
Section 1. Pain
 Chapter 12.Pain: Pathophysiology and Management
 Chapter 13.Chest Discomfort
 Chapter 14.Abdominal Pain
 Chapter 15.Headache
 Chapter 16.Back and Neck Pain

Section 2. Alterations in Body Temperature
 Chapter 17.Fever and Hyperthermia
 Chapter 18.Fever and Rash
Chapter e5.Atlas of Rashes Associated with Fever
 Chapter 19.Fever of Unknown Origin
 Chapter 20.Hypothermia and Frostbite

Section 3. Nervous System Dysfunction
 Chapter 21.Syncope
 Chapter 22.Dizziness and Vertigo
 Chapter 23.Weakness and Paralysis
 Chapter 24.Gait and Balance Disorders
 Chapter 25.Numbness, Tingling, and Sensory Loss
 Chapter 26.Confusion and Delirium
Chapter e6.Memory Loss
 Chapter 27.Aphasia, Memory Loss, and Other Focal Cerebral Disorders
 Chapter 28.Sleep Disorders

Section 4. Disorders of Eyes, Ears, Nose, and Throat
 Chapter 29.Disorders of the Eye
 Chapter 30.Disorders of Smell, Taste, and Hearing
 Chapter 31.Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections
 Chapter 32.Oral Manifestations of Disease
Chapter e7.Atlas of Oral Manifestations of Disease

Section 5. Alterations in Circulatory and Respiratory Functions
 Chapter 33.Dyspnea and Pulmonary Edema
 Chapter 34.Cough and Hemoptysis
 Chapter 35.Hypoxia and Cyanosis
 Chapter 36.Edema
Chapter e8.Approach to the Patient with a Heart Murmur
 Chapter 37.Palpitations

Section 6. Alterations in Gastrointestinal Function
 Chapter 38.Dysphagia
 Chapter 39.Nausea, Vomiting, and Indigestion
 Chapter 40.Diarrhea and Constipation
 Chapter 41.Weight Loss
 Chapter 42.Gastrointestinal Bleeding
 Chapter 43.Jaundice
 Chapter 44.Abdominal Swelling and Ascites

Section 7. Alterations in Renal and Urinary Tract Function
 Chapter 45.Azotemia and Urinary Abnormalities
Chapter e9.Atlas of Urinary Sediments and Renal Biopsies
 Chapter 46.Fluid and Electrolyte Disturbances
 Chapter 47.Hypercalcemia and Hypocalcemia
 Chapter 48.Acidosis and Alkalosis

Section 8. Alterations in Sexual Function and Reproduction
 Chapter 49.Sexual Dysfunction
 Chapter 50.Hirsutism and Virilization
 Chapter 51.Menstrual Disorders and Pelvic Pain

Section 9. Alterations in the Skin
 Chapter 52.Approach to the Patient with a Skin Disorder
 Chapter 53.Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
 Chapter 54.Skin Manifestations of Internal Disease
 Chapter 55.Immunologically Mediated Skin Diseases
 Chapter 56.Cutaneous Drug Reactions
 Chapter 57.Photosensitivity and Other Reactions to Light
Chapter e10.Atlas of Skin Manifestations of Internal Disease

Section 10. Hematologic Alterations
 Chapter 58.Anemia and Polycythemia
 Chapter 59.Bleeding and Thrombosis
 Chapter 60.Enlargement of Lymph Nodes and Spleen
 Chapter 61.Disorders of Granulocytes and Monocytes
Chapter e11.Atlas of Hematology and Analysis of Peripheral Blood Smears

Part 3. Genetics and Disease
 Chapter 62.Principles of Human Genetics
 Chapter 63.Chromosome Disorders
 Chapter 64.The Practice of Genetics in Clinical Medicine
 Chapter 65.Gene Therapy in Clinical Medicine

Part 4. Regenerative Medicine
 Chapter 66.Stem Cell Biology
 Chapter 67.Applications of Stem Cell Biology in Clinical Medicine
 Chapter 68.Hematopoietic Stem Cells
 Chapter 69.Tissue Engineering

Part 5. Nutrition
 Chapter 70.Nutritional Requirements and Dietary Assessment
 Chapter 71.Vitamin and Trace Mineral Deficiency and Excess
 Chapter 72.Malnutrition and Nutritional Assessment
 Chapter 73.Enteral and Parenteral Nutrition Therapy
 Chapter 74.Biology of Obesity
 Chapter 75.Evaluation and Management of Obesity
 Chapter 76.Eating Disorders

Part 6. Oncology and Hematology
Section 1. Neoplastic Disorders
 Chapter 77.Approach to the Patient with Cancer
 Chapter 78.Prevention and Early Detection of Cancer
 Chapter 79.Cancer Genetics
 Chapter 80.Cancer Cell Biology and Angiogenesis
 Chapter 81.Principles of Cancer Treatment
 Chapter 82.Infections in Patients with Cancer
 Chapter 83.Cancer of the Skin
 Chapter 84.Head and Neck Cancer
 Chapter 85.Neoplasms of the Lung
 Chapter 86.Breast Cancer
 Chapter 87.Gastrointestinal Tract Cancer
 Chapter 88.Tumors of the Liver and Biliary Tree
 Chapter 89.Pancreatic Cancer
 Chapter 90.Bladder and Renal Cell Carcinomas
 Chapter 91.Benign and Malignant Diseases of the Prostate
 Chapter 92.Testicular Cancer
 Chapter 93.Gynecologic Malignancies
 Chapter 94.Soft Tissue and Bone Sarcomas and Bone Metastases
 Chapter 95.Carcinoma of Unknown Primary
 Chapter 96.Paraneoplastic Syndromes: Endocrinologic/Hematologic
 Chapter 97.Paraneoplastic Neurologic Syndromes
Chapter e12.Thymoma
Chapter e13.Late Consequences of Cancer and Its Treatment

Section 2. Hematopoietic Disorders
 Chapter 98.Iron Deficiency and Other Hypoproliferative Anemias
 Chapter 99.Disorders of Hemoglobin
 Chapter 100.Megaloblastic Anemias
 Chapter 101.Hemolytic Anemias and Anemia Due to Acute Blood Loss
 Chapter 102.Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
 Chapter 103.Polycythemia Vera and Other Myeloproliferative Diseases
 Chapter 104.Acute and Chronic Myeloid Leukemia
 Chapter 105.Malignancies of Lymphoid Cells
 Chapter 106.Plasma Cell Disorders
 Chapter 107.Transfusion Biology and Therapy
 Chapter 108.Hematopoietic Cell Transplantation

Section 3. Disorders of Hemostasis
 Chapter 109.Disorders of Platelets and Vessel Wall
 Chapter 110.Coagulation Disorders
 Chapter 111.Venous Thrombosis
 Chapter 112.Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

Part 7. Infectious Diseases
Section 1. Basic Considerations in Infectious Diseases
 Chapter 113.Introduction to Infectious Diseases: Host–Pathogen Interactions
 Chapter 114.Molecular Mechanisms of Microbial Pathogenesis
 Chapter 115.Approach to the Acutely Ill Infected Febrile Patient
 Chapter 116.Immunization Principles and Vaccine Use
 Chapter 117.Health Advice for International Travel
Chapter e14.Laboratory Diagnosis of Infectious Diseases

Section 2. Clinical Syndromes: Community-Acquired Infections
 Chapter 118.Infective Endocarditis
 Chapter 119.Infections of the Skin, Muscle, and Soft Tissues
 Chapter 120.Osteomyelitis
 Chapter 121.Intraabdominal Infections and Abscesses
 Chapter 122.Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
 Chapter 123.Clostridium difficile–Associated Disease, Including Pseudomembranous Colitis
 Chapter 124.Sexually Transmitted Infections: Overview and Clinical Approach
Chapter e15.Infectious Complications of Burns and Bites

Section 3. Clinical Syndromes: Health Care–Associated Infections
 Chapter 125.Health Care–Associated Infections
 Chapter 126.Infections in Transplant Recipients

Section 4. Approach to Therapy for Bacterial Diseases
 Chapter 127.Treatment and Prophylaxis of Bacterial Infections

Section 5. Diseases Caused by Gram-Positive Bacteria
 Chapter 128.Pneumococcal Infections
 Chapter 129.Staphylococcal Infections
 Chapter 130.Streptococcal and Enterococcal Infections
 Chapter 131.Diphtheria and Other Infections Caused by Corynebacteria and Related Species
 Chapter 132.Infections Caused by Listeria monocytogenes
 Chapter 133.Tetanus
 Chapter 134.Botulism
 Chapter 135.Gas Gangrene and Other Clostridial Infections

Section 6. Diseases Caused by Gram-Negative Bacteria
 Chapter 136.Meningococcal Infections
 Chapter 137.Gonococcal Infections
 Chapter 138.Moraxella Infections
 Chapter 139.Haemophilus Infections
 Chapter 140.Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
 Chapter 141.Legionella Infection
 Chapter 142.Pertussis and Other Bordetella Infections
 Chapter 143.Diseases Caused by Gram-Negative Enteric Bacilli
 Chapter 144.Helicobacter pylori Infections
 Chapter 145.Infections Due to Pseudomonas Species and Related Organisms
 Chapter 146.Salmonellosis
 Chapter 147.Shigellosis
 Chapter 148.Infections Due to Campylobacter and Related Species
 Chapter 149.Cholera and Other Vibrioses
 Chapter 150.Brucellosis
 Chapter 151.Tularemia
 Chapter 152.Plague and Other Yersinia Infections
 Chapter 153.Bartonella Infections, Including Cat-Scratch Disease
 Chapter 154.Donovanosis

Section 7. Miscellaneous Bacterial Infections
 Chapter 155.Nocardiosis
 Chapter 156.Actinomycosis
 Chapter 157.Infections Due to Mixed Anaerobic Organisms

Section 8. Mycobacterial Diseases
 Chapter 158.Tuberculosis
 Chapter 159.Leprosy (Hansen's Disease)
 Chapter 160.Nontuberculous Mycobacteria
 Chapter 161.Antimycobacterial Agents

Section 9. Spirochetal Diseases
 Chapter 162.Syphilis
 Chapter 163.Endemic Treponematoses
 Chapter 164.Leptospirosis
 Chapter 165.Relapsing Fever
 Chapter 166.Lyme Borreliosis

Section 10. Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
 Chapter 167.Rickettsial Diseases
 Chapter 168.Infections Due to Mycoplasmas
 Chapter 169.Chlamydial Infections

Section 11. Viral Diseases: General Considerations
 Chapter 170.Medical Virology
 Chapter 171.Antiviral Chemotherapy, Excluding Antiretroviral Drugs

Section 12. Infections Due to DNA Viruses
 Chapter 172.Herpes Simplex Viruses
 Chapter 173.Varicella-Zoster Virus Infections
 Chapter 174.Epstein-Barr Virus Infections, Including Infectious Mononucleosis
 Chapter 175.Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
 Chapter 176.Molluscum Contagiosum, Monkeypox, and Other Poxviruses, Excluding Smallpox Virus
 Chapter 177.Parvovirus Infections
 Chapter 178.Human Papillomavirus Infections

Section 13. Infections Due to DNA and RNA Respiratory Viruses
 Chapter 179.Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
 Chapter 180.Influenza

Section 14. Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
 Chapter 181.The Human Retroviruses
 Chapter 182.Human Immunodeficiency Virus Disease: AIDS and Related Disorders

Section 15. Infections Due to RNA Viruses
 Chapter 183.Viral Gastroenteritis
 Chapter 184.Enteroviruses and Reoviruses
 Chapter 185.Measles (Rubeola)
 Chapter 186.Rubella (German Measles)
 Chapter 187.Mumps
 Chapter 188.Rabies and Other Rhabdovirus Infections
 Chapter 189.Infections Caused by Arthropod- and Rodent-Borne Viruses
 Chapter 190.Ebola and Marburg Viruses

Section 16. Fungal and Algal Infections
 Chapter 191.Diagnosis and Treatment of Fungal Infections
 Chapter 192.Histoplasmosis
 Chapter 193.Coccidioidomycosis
 Chapter 194.Blastomycosis
 Chapter 195.Cryptococcosis
 Chapter 196.Candidiasis
 Chapter 197.Aspergillosis
 Chapter 198.Mucormycosis
 Chapter 199.Miscellaneous Mycoses and Algal Infections
 Chapter 200.Pneumocystis Infection

Section 17. Protozoal and Helminthic Infections: General Considerations
Chapter e16.Laboratory Diagnosis of Parasitic Infections
 Chapter 201.Agents Used to Treat Parasitic Infections
Chapter e17.Pharmacology of Agents Used to Treat Parasitic Infections

Section 18. Protozoal Infections
 Chapter 202.Amebiasis and Infection with Free-Living Amebas
 Chapter 203.Malaria
 Chapter 204.Babesiosis
Chapter e18.Atlas of Blood Smears of Malaria and Babesiosis
 Chapter 205.Leishmaniasis
 Chapter 206.Trypanosomiasis
 Chapter 207.Toxoplasma Infections
 Chapter 208.Protozoal Intestinal Infections and Trichomoniasis

Section 19. Helminthic Infections
 Chapter 209.Trichinella and Other Tissue Nematodes
 Chapter 210.Intestinal Nematodes
 Chapter 211.Filarial and Related Infections
 Chapter 212.Schistosomiasis and Other Trematode Infections
 Chapter 213.Cestodes

Part 8. Bioterrorism and Clinical Medicine
 Chapter 214.Microbial Bioterrorism
 Chapter 215.Chemical Bioterrorism
 Chapter 216.Radiation Bioterrorism

Part 9. Disorders of the Cardiovascular System
Section 1. Introduction to Cardiovascular Disorders
 Chapter 217.Basic Biology of the Cardiovascular System
 Chapter 218.Epidemiology of Cardiovascular Disease
 Chapter 219.Approach to the Patient with Possible Cardiovascular Disease

Section 2. Diagnosis of Cardiovascular Disorders
 Chapter 220.Physical Examination of the Cardiovascular System
 Chapter 221.Electrocardiography
Chapter e19.Atlas of Electrocardiography
 Chapter 222.Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
Chapter e20.Atlas of Noninvasive Cardiac Imaging
 Chapter 223.Diagnostic Cardiac Catheterization and Angiography

Section 3. Disorders of Rhythm
 Chapter 224.Principles of Electrophysiology
 Chapter 225.The Bradyarrhythmias
 Chapter 226.The Tachyarrhythmias
Chapter e21.Atlas of Cardiac Arrhythmias

Section 4. Disorders of the Heart
 Chapter 227.Heart Failure and Cor Pulmonale
 Chapter 228.Cardiac Transplantation and Prolonged Assisted Circulation
 Chapter 229.Congenital Heart Disease in the Adult
 Chapter 230.Valvular Heart Disease
 Chapter 231.Cardiomyopathy and Myocarditis
 Chapter 232.Pericardial Disease
 Chapter 233.Tumors and Trauma of the Heart
 Chapter 234.Cardiac Manifestations of Systemic Disease

Section 5. Vascular Disease
 Chapter 235.The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Chapter e22.Atlas of Atherosclerosis
 Chapter 236.The Metabolic Syndrome
 Chapter 237.Ischemic Heart Disease
 Chapter 238.Unstable Angina and Non-ST-Elevation Myocardial Infarction
 Chapter 239.ST-Segment Elevation Myocardial Infarction
 Chapter 240.Percutaneous Coronary Intervention
Chapter e23.Atlas of Percutaneous Revascularization
 Chapter 241.Hypertensive Vascular Disease
 Chapter 242.Diseases of the Aorta
 Chapter 243.Vascular Diseases of the Extremities
 Chapter 244.Pulmonary Hypertension

Part 10. Disorders of the Respiratory System
Section 1. Diagnosis of Respiratory Disorders
 Chapter 245.Approach to the Patient with Disease of the Respiratory System
 Chapter 246.Disturbances of Respiratory Function
 Chapter 247.Diagnostic Procedures in Respiratory Disease
Chapter e24.Atlas of Chest Imaging

Section 2. Diseases of the Respiratory System
 Chapter 248.Asthma
 Chapter 249.Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
 Chapter 250.Environmental Lung Disease
 Chapter 251.Pneumonia
 Chapter 252.Bronchiectasis and Lung Abscess
 Chapter 253.Cystic Fibrosis
 Chapter 254.Chronic Obstructive Pulmonary Disease
 Chapter 255.Interstitial Lung Diseases
Chapter e40.New! Altitude Illness: Acute Mountain Sickness, High-Altitude Pulmonary Edema, and High-Altitude Cerebral Edema
 Chapter 256.Deep Venous Thrombosis and Pulmonary Thromboembolism
 Chapter 257.Disorders of the Pleura and Mediastinum
 Chapter 258.Disorders of Ventilation
 Chapter 259.Sleep Apnea
 Chapter 260.Lung Transplantation

Part 11. Critical Care Medicine
Section 1. Respiratory Critical Care
 Chapter 261.Principles of Critical Care Medicine
 Chapter 262.Acute Respiratory Distress Syndrome
 Chapter 263.Mechanical Ventilatory Support

Section 2. Shock and Cardiac Arrest
 Chapter 264.Approach to the Patient with Shock
 Chapter 265.Severe Sepsis and Septic Shock
 Chapter 266.Cardiogenic Shock and Pulmonary Edema
 Chapter 267.Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

Section 3. Neurologic Critical Care
 Chapter 268.Coma
 Chapter 269.Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage

Section 4. Oncologic Emergencies
 Chapter 270.Oncologic Emergencies

Part 12. Disorders of the Kidney and Urinary Tract
 Chapter 271.Cellular and Molecular Biology of the Kidney
 Chapter 272.Adaptation of the Kidney to Renal Injury
 Chapter 273.Acute Renal Failure
 Chapter 274.Chronic Kidney Disease
 Chapter 275.Dialysis in the Treatment of Renal Failure
 Chapter 276.Transplantation in the Treatment of Renal Failure
 Chapter 277.Glomerular Diseases
 Chapter 278.Polycystic Kidney Disease and Other Inherited Tubular Disorders
 Chapter 279.Tubulointerstitial Diseases of the Kidney
 Chapter 280.Vascular Injury to the Kidney
 Chapter 281.Nephrolithiasis
 Chapter 282.Urinary Tract Infections, Pyelonephritis, and Prostatitis
 Chapter 283.Urinary Tract Obstruction

Part 13. Disorders of the Gastrointestinal System
Section 1. Disorders of the Alimentary Tract
 Chapter 284.Approach to the Patient with Gastrointestinal Disease
 Chapter 285.Gastrointestinal Endoscopy
Chapter e25.Video Atlas of Gastrointestinal Endoscopy
 Chapter 286.Diseases of the Esophagus
 Chapter 287.Peptic Ulcer Disease and Related Disorders
 Chapter 288.Disorders of Absorption
 Chapter 289.Inflammatory Bowel Disease
 Chapter 290.Irritable Bowel Syndrome
 Chapter 291.Diverticular Disease and Common Anorectal Disorders
 Chapter 292.Mesenteric Vascular Insufficiency
 Chapter 293.Acute Intestinal Obstruction
 Chapter 294.Acute Appendicitis and Peritonitis

Section 2. Liver and Biliary Tract Disease
 Chapter 295.Approach to the Patient with Liver Disease
 Chapter 296.Evaluation of Liver Function
 Chapter 297.The Hyperbilirubinemias
 Chapter 298.Acute Viral Hepatitis
 Chapter 299.Toxic and Drug-Induced Hepatitis
 Chapter 300.Chronic Hepatitis
 Chapter 301.Alcoholic Liver Disease
 Chapter 302.Cirrhosis and Its Complications
Chapter e26.Atlas of Liver Biopsies
 Chapter 303.Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
 Chapter 304.Liver Transplantation
 Chapter 305.Diseases of the Gallbladder and Bile Ducts

Section 3. Disorders of the Pancreas
 Chapter 306.Approach to the Patient with Pancreatic Disease
 Chapter 307.Acute and Chronic Pancreatitis

Part 14. Disorders of the Immune System, Connective Tissue, and Joints
Section 1. The Immune System in Health and Disease
 Chapter 308.Introduction to the Immune System
 Chapter 309.The Major Histocompatibility Complex
 Chapter 310.Primary Immune Deficiency Diseases
Chapter e27.Primary Immunodeficiencies Associated with or Secondary to Other Diseases

Section 2. Disorders of Immune-Mediated Injury
 Chapter 311.Allergies, Anaphylaxis, and Systemic Mastocytosis
 Chapter 312.Autoimmunity and Autoimmune Diseases
 Chapter 313.Systemic Lupus Erythematosus
 Chapter 314.Rheumatoid Arthritis
 Chapter 315.Acute Rheumatic Fever
 Chapter 316.Systemic Sclerosis (Scleroderma) and Related Disorders
 Chapter 317.Sjögren's Syndrome
 Chapter 318.The Spondyloarthritides
 Chapter 319.The Vasculitis Syndromes
Chapter e28.Atlas of Clinical Imaging of the Vasculitic Diseases
 Chapter 320.Behçet's Syndrome
 Chapter 321.Relapsing Polychondritis
 Chapter 322.Sarcoidosis
 Chapter 323.Familial Mediterranean Fever
 Chapter 324.Amyloidosis

Section 3. Disorders of the Joints and Adjacent Tissues
 Chapter 325.Approach to Articular and Musculoskeletal Disorders
 Chapter 326.Osteoarthritis
 Chapter 327.Gout and Other Crystal-Associated Arthropathies
 Chapter 328.Infectious Arthritis
 Chapter 329.Fibromyalgia
 Chapter 330.Arthritis Associated with Systemic Disease and Other Arthritides
 Chapter 331.Periarticular Disorders of the Extremities

Part 15. Endocrinology and Metabolism
Section 1. Endocrinology
 Chapter 332.Principles of Endocrinology
 Chapter 333.Disorders of the Anterior Pituitary and Hypothalamus
 Chapter 334.Disorders of the Neurohypophysis
 Chapter 335.Disorders of the Thyroid Gland
 Chapter 336.Disorders of the Adrenal Cortex
 Chapter 337.Pheochromocytoma
 Chapter 338.Diabetes Mellitus
 Chapter 339.Hypoglycemia
 Chapter 340.Disorders of the Testes and Male Reproductive System
 Chapter 341.The Female Reproductive System: Infertility and Contraception
 Chapter 342.The Menopause Transition and Postmenopausal Hormone Therapy
 Chapter 343.Disorders of Sex Development
 Chapter 344.Endocrine Tumors of the Gastrointestinal Tract and Pancreas
 Chapter 345.Disorders Affecting Multiple Endocrine Systems

Section 2. Disorders of Bone and Mineral Metabolism
 Chapter 346.Bone and Mineral Metabolism in Health and Disease
 Chapter 347.Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemic Disorders
 Chapter 348.Osteoporosis
 Chapter 349.Paget Disease and Other Dysplasias of Bone

Section 3. Disorders of Intermediary Metabolism
 Chapter 350.Disorders of Lipoprotein Metabolism
 Chapter 351.Hemochromatosis
 Chapter 352.The Porphyrias
 Chapter 353.Disorders of Purine and Pyrimidine Metabolism
 Chapter 354.Wilson Disease
 Chapter 355.Lysosomal Storage Diseases
 Chapter 356.Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
 Chapter 357.Heritable Disorders of Connective Tissue
 Chapter 358.Inherited Disorders of Amino Acid Metabolism in Adults
 Chapter 359.Inherited Defects of Membrane Transport
Chapter e29.Atlas of Clinical Manifestations of Metabolic Diseases

Part 16. Neurologic Disorders
Section 1. Diagnosis of Neurologic Disorders
 Chapter 360.Mechanisms of Neurologic Diseases
 Chapter 361.Approach to the Patient with Neurologic Disease
 Chapter 362.Neuroimaging in Neurologic Disorders
Chapter e30.Atlas of Neuroimaging
Chapter e31.Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG
Chapter e32.Technique of Lumbar Puncture

Section 2. Diseases of the Central Nervous System
 Chapter 363.Seizures and Epilepsy
 Chapter 364.Cerebrovascular Diseases
 Chapter 365.Dementia
 Chapter 366.Parkinson's Disease and Other Extrapyramidal Movement Disorders
 Chapter 367.Hyperkinetic Movement Disorders
 Chapter 368.Ataxic Disorders
 Chapter 369.Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
 Chapter 370.Disorders of the Autonomic Nervous System
 Chapter 371.Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders
 Chapter 372.Diseases of the Spinal Cord
 Chapter 373.Concussion and Other Head Injuries
 Chapter 374.Primary and Metastatic Tumors of the Nervous System
 Chapter 375.Multiple Sclerosis and Other Demyelinating Diseases
 Chapter 376.Meningitis, Encephalitis, Brain Abscess, and Empyema
 Chapter 377.Chronic and Recurrent Meningitis
 Chapter 378.Prion Diseases

Section 3. Nerve and Muscle Disorders
 Chapter 379.Peripheral Neuropathy
 Chapter 380.Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
 Chapter 381.Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
 Chapter 382.Muscular Dystrophies and Other Muscle Diseases
 Chapter 383.Polymyositis, Dermatomyositis, and Inclusion Body Myositis
Chapter e33.Special Issues in Inpatient Neurologic Consultation

Section 4. Chronic Fatigue Syndrome
 Chapter 384.Chronic Fatigue Syndrome

Section 5. Psychiatric Disorders
 Chapter 385.Biology of Psychiatric Disorders
 Chapter 386.Mental Disorders

Section 6. Alcoholism and Drug Dependency
 Chapter 387.Alcohol and Alcoholism
 Chapter 388.Opioid Drug Abuse and Dependence
 Chapter 389.Cocaine and Other Commonly Abused Drugs
 Chapter 390.Nicotine Addiction

Part 17. Poisoning, Drug Overdose, and Envenomation
Chapter e34.Heavy Metal Poisoning
Chapter e35.Poisoning and Drug Overdosage
 Chapter 391.Disorders Caused by Reptile Bites and Marine Animal Exposures
 Chapter 392.Ectoparasite Infestations and Arthropod Bites and Stings

Part 18. e-Chapters from International Advisory Editors
Chapter e36.Pulmonary Biomarkers in COPD
Chapter e37.Chagas' Disease: Advances in Diagnosis and Management
Chapter e38.The Polypill
Chapter e39.Mitochondrial DNA and Heritable Traits and Diseases

Appendix: Laboratory Values of Clinical Importance





 The e-chapter logo indicates a Harrison's chapter that is available online and on the Harrison's DVD.