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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11e
Chapter 2. Membrane Transporters and Drug Response
Sections: Membrane Transporters and Drug Response: Introduction, Membrane Transporters in Therapeutic Drug Responses, Membrane Transporters and Adverse Drug Responses, Basic Mechanisms of Membrane Transport, Kinetics of Transport, Vectorial Transport, Molecular Structures of Transporters, Transporter Superfamilies in the Human Genome, Genetic Variation in Membrane Transporters: Implications for Clinical Drug Response, Transporters Involved in Pharmacokinetics, Transporters Involved in Pharmacodynamics: Drug Action in the Brain, Blood–Brain Barrier and Blood–CSF Barrier, Bibliography.
Topics Discussed: drug response; membrane transport proteins; membrane transport, drug receptors, and drug response.
Excerpt:
"Transporters are membrane proteins that are present in all organisms. These proteins control the influx of essential nutrients and ions and the efflux of cellular waste, environmental toxins, and other xenobiotics. Consistent with their critical roles in cellular homeostasis, approximately 2000 genes in the human genome (~6% of the total number of genes) code for transporters or transporter-related proteins. The functions of membrane transporters may be facilitated (equilibrative, not requiring energy) or active (requiring energy). ..."
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